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October 1990

Autoantibodies From Patients With Localized and Generalized Bullous Pemphigoid Immunoprecipitate the Same 230-kd Keratinocyte Antigen

Author Affiliations


From the Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Md (Drs Domloge-Hultsch and Yancey); the Department of Dermatology, National Naval Medical Center, Bethesda, Md (LCDR Utecht); and the Dermatology Service, Walter Reed Army Medical Center, Washington, DC (LTC(P) James).

Arch Dermatol. 1990;126(10):1337-1341. doi:10.1001/archderm.1990.01670340089015

• Two patients demonstrating the typical clinical, histologic, and immunopathologic features of nonscarring localized bullous pemphigoid are described. These patients possess circulating IgG autoantibodies that bind the epidermal side of 1.0-mol/L sodium chloride—split human skin in indirect immunofluorescence microscopy. Immunoprecipitation studies demonstrate that these patients have circulating autoantibodies that immunoprecipitate the same 230-kd bullous pemphigoid antigen that is precipitated by autoantibodies from patients with generalized bullous pemphigoid. These findings indicate that localized bullous pemphigoid is a true clinical variant of generalized pemphigoid rather than a separate nosologic entity.

(Arch Dermatol. 1990;126:1337-1341)