edited by Robert L. Bronaugh and Howard I. Maibach, 632 pp, with illus, $125, New York, NY, Marcel Dekker Inc, 1989.
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The first edition of this book, published in 1985, was the result of a symposium on percutaneous absorption held at the Food and Drug Administration in 1983. This area of dermatology continues to expand rapidly, fueled by the pharmaceutical industry's interest in the skin as a route for systemic drug delivery and the government's concern over the skin as a route of absorption for toxic materials. As a result, the second edition of Percutaneous Absorption has been published recently to incorporate important new material and expand that previously published.
As before, the book is divided into three sections (mechanisms of absorption, methodology, and drug delivery), and almost all major areas of interest to workers in the field have been covered. In the mechanisms section, topics such as mathematical models, structure-activity correlations, penetration enhancers, regional variation, and studies on the skin of infants (to name a few) are covered. A particularly
Franz TJ. Percutaneous Absorption: Mechanisms—Methodology—Drug Delivery. Arch Dermatol. 1990;126(10):1384. doi:10.1001/archderm.1990.01670340140037