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November 1990

Detection of the Interferon-gamma-Induced Protein 10 in Psoriasiform Dermatitis of Acquired Immunodeficiency Syndrome

Author Affiliations

From the Departments of Pathology, Division of Dermatopathology (Drs Smoller, McNutt, and Gray and Ms Hsu) and Medicine, Division of Dermatology (Drs Smoller, McNutt, Krueger, and Gottlieb), New York (NY) Hospital-Cornell University Medical Center, and the Department of Dermatology, Rockefeller University Hospital (Drs McNutt, Krueger, and Gottlieb), New York, NY. Dr Smoller is now with the Departments of Pathology and Dermatology, Stanford (Calif) University Medical Center.

Arch Dermatol. 1990;126(11):1457-1461. doi:10.1001/archderm.1990.01670350071010

• Interferon-gamma-induced protein 10 is a 10-kd protein produced by human keratinocytes following an exposure to interferon gamma. Keratinocytes within psoriatic plaques and within delayed-type hypersensitivity reactions have been shown to stain strongly with an affinity-purified rabbit antibody prepared against interferon-gamma-induced protein 10, suggesting a possible role for interferon gamma in the production of the lesions. A psoriasiform eruption has been seen in patients with acquired immunodeficiency syndrome (AIDS). Its severity appears to correlate with the degree of immunodeficiency in the early stages of AIDS. We stained 10 lesions of psoriasiform dermatitis of AIDS with the anti-interferon-gamma-induced protein 10 antibody using immunoperoxidase techniques. As controls, we studied 10 lesions of non-AIDS psoriasis, six lesions of seborrheic dermatitis with psoriasiform hyperplasia, one lesion of lichen simplex chronicus, and four biopsy specimens of normal skin from patients with AIDS. In addition, normal skin specimens taken from patients with AIDS and human immunodeficiency virus-negative patients at time of autopsy were examined. An identical, strong and diffuse staining pattern was seen in all cases of psoriasiform dermatitis of AIDS, non-AIDS psoriasis, seborrheic dermatitis, and lichen simplex chronicus. The specimens of normal skin showed only weak basal layer staining with anti-interferon-gamma-induced protein 10. Thus, the presence of interferon-gamma-induced protein 10 in keratinocytes was associated with psoriasiform hyperplasia and could be detected in both AIDS-associated and classic psoriasis.

(Arch Dermatol. 1990;126:1457-1461)