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Article
December 1990

Primary Dapsone-Resistant Hansen's Disease in CaliforniaExperience With Over 100 Mycobacterium leprae Isolates

Author Affiliations

From the Kuzell Institute for Arthritis and Infectious Diseases, Medical Research Institute of San Francisco (Calif), and Gillis W. Long Hansen's Disease Center, Carville, La (Drs Gelber and Byrd and Mss Murray, Siu, and Tsang); and Section of Dermatology, University of Southern California School of Medicine, Los Angeles (Dr Rea).

Arch Dermatol. 1990;126(12):1584-1586. doi:10.1001/archderm.1990.01670360048006
Abstract

• We found that in the years 1978 through 1981 only one of 54 previously untreated patients with Hansen's disease was found to harbor dapsone-resistant Mycobacterium leprae. That single strain was only partially resistant, ie, it was resistant to 0.0001% dapsone in a mouse diet but not to higher concentrations. During the years 1983 through 1988, Mleprae from 47 previously untreated patients presenting to clinics in San Francisco, Calif, and Los Angeles, Calif, grew in mice. None of these strains was found to be dapsone resistant. Thus, from 1978 through 1988 only one of 101 M leprae isolates obtained from skin biopsy specimens from patients with leprosy was found to be resistant to dapsone. We have concluded that primary dapsone resistance still does not appear to be a significant problem in California. Owing to the fact that our single resistant case and those reported from international sources are, in general, partially resistant, the potential importance of partial dapsone resistance is discussed.

(Arch Dermatol. 1990;126:1584-1585)

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