• A 30-year-old woman with congenital rickets and autosomal recessive ichthyosis developed impetigo herpetiformis in the second trimester of her first pregnancy. This condition was temporally related to her discontinuation of vitamin D supplements and subsequent hypocalcemia. No associated systemic symptoms were observed, and a healthy baby was delivered prematurely at 34 weeks' gestation. This report supports the association between hypocalcemia and impetigo herpetiformis and raises theoretical questions regarding a relationship between vitamin D metabolism and various epidermal hyperproliferative states.
(Arch Dermatol. 1991;127:91-95)
Holm AL, Goldsmith LA. Impetigo Herpetiformis Associated With Hypocalcemia of Congenital Rickets. Arch Dermatol. 1991;127(1):91-95. doi:10.1001/archderm.1991.01680010101017