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Article
February 1991

A Double-blind Controlled Comparison of Generic and Trade-Name Topical Steroids Using the Vasoconstriction Assay

Author Affiliations

From the Division of Dermatology, Department of Medicine, Duke University Medical Center, Durham, NC.

Arch Dermatol. 1991;127(2):197-201. doi:10.1001/archderm.1991.01680020065006
Abstract

• Six generic formulations of five topical steroids were compared for bioequivalence with their trade-name counterparts using an in vivo vasoconstriction assay. Two of six generic formulations were found to show significantly less vasoconstriction than the respective trade-name topical steroids. The issue of generic equivalence of topical steroids is discussed, with particular emphasis on the vagaries of the vasoconstriction assay.

(Arch Dermatol. 1991;127:197-201)

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