To the Editor.—
T-cell prolymphocytic leukemia (T-PLL) represents a rare form of lymphoproliferative disorder that carries a grave prognostic consequence. We describe an unusual presentation of a case, and we believe that the pattern of immunophenotypic expression of the leukemic cells provides a useful distinguishing feature from other forms of leukemias/lymphomas.
Report of a Case.—
An 84-year-old white man presented in June 1989 with a 6-week history of a florid nonblanching macular erythema affecting the face and upper chest only (Figure). Physical examination was unremarkable; there was neither lymphadenopathy nor hepatosplenomegaly.Laboratory findings revealed marked leukocytosis with an atypical lymphocytosis of 36.9 × 109/L. The cytoplasm demonstrated deep basophilia, and the nuclei showed a regular outline with slight indentation. The nucleoli were inconspicuous under light microscopy. With the use of membrane marker analysis against a panel of monoclonal antibodies, the peripheral mononuclear cells demonstrated the following membrane markers:
Yu RCH, Verbov JL, Rugman FP. An Unusual Case of T-Lymphocytic Leukemia With Coexpression of Helper and Suppressor Surface Markers. Arch Dermatol. 1991;127(6):909-910. doi:10.1001/archderm.1991.01680050155026