• A double-blind controlled study was performed on a patient with long-standing yellow nail syndrome to investigate the potential beneficial role of topical vitamin E solution for the nail changes seen in this disorder. Three nails received active solution containing DL-α-tocopherol in dimethyl sulfoxide; three nails received dimethyl sulfoxide only; and the remainder were untreated. After 6 months of therapy, the three nails treated with active solution showed marked clinical improvement and a corresponding increase in nail growth rates. Dimethyl sulfoxide alone produced a small increase in nail growth rate and slight clinical improvement. Active solution was then applied to all of the nails for a further 6 months, resulting in clinical improvement and increased nail growth rates in the remaining nails. These beneficial effects require further study.
(Arch Dermatol. 1991;127:1023-1028)
Williams HC, Buffham R, Vivier AD. Successful Use of Topical Vitamin E Solution in the Treatment of Nail Changes in Yellow Nail Syndrome. Arch Dermatol. 1991;127(7):1023-1028. doi:10.1001/archderm.1991.01680060097012