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July 1991

Treatment of Cutaneous Sarcoidosis With ChloroquineReview of the Literature

Author Affiliations

From the Division of Dermatology, Vanderbilt School of Medicine, Nashville, Tenn. Dr Horowitz is in private practice in Nashville.

Arch Dermatol. 1991;127(7):1034-1040. doi:10.1001/archderm.1991.01680060108015

• Systemic corticosteroids may be either contraindicated or not efficacious in treating the cutaneous manifestations occurring in 20% to 35% of patients with systemic sarcoidosis. Chloroquine phosphate has been reported to be a valuable alternative therapy for cutaneous lesions of sarcoidosis. With a judiciously determined daily dosage and regular 6-month ophthalmologic follow-up examinations, the risk of developing retinopathy can be avoided, because the daily dosage rate rather than total dose accumulation determines the development of chloroquine-induced retinopathy. We reviewed the efficacy and safety of chloroquine and its role in the treatment of cutaneous sarcoidosis.

(Arch Dermatol. 1991;127:1034-1040)