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August 1991

Unusual Skin Tumors in Langerhans Cell Histiocytes

Author Affiliations

Department of Dermatology Faculty of Medicine 41011 Avda Republica Argentina 22-5:D Sevilla, Spain

Arch Dermatol. 1991;127(8):1237-1238. doi:10.1001/archderm.1991.01680070139023

To the Editor.—  I read with great interest the article by Santhosh-Kumar et al on "Unusual Skin Tumors in Langerhans Cell Histiocytosis."1 I was particularly interested in the statement "the large skin tumors have not been previously described as appearing with LHC." In 1988,I and a number of my colleagues from First October Hospital of Madrid (Spain) published in Actas Dermo-Sifiliográficas2 the results of a case study on pure cutaneous histiocytosis X in which the symptoms, dermatopathologic, immunochemical, and electronic microscopic studies were the same: swelling growing to a cylindrical mass across the axillary and inguinal region; dermal histiocytic infiltrates and granulomas; these cells stained with immunoperoxidase S100 and showed numerous Birbeck granules.I recently received slides of a young male patient that, when reviewed, convinced me that this was the same case. The patient was sent to me and subsequent clinical examination and histopathologic, immunohistochemical, and electronic microscopic studies bore this out.

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