† The central tenet of invisible dermatology is that visible lesions represent a late stage of development. The eye is an unreliable instrument for judging the normalcy of skin. In chronic widespread dermatoses, the uninvolved skin is at least physiologically abnormal. Recently healed skin is always abnormal. Recognition of occult changes will have a substantial impact on the prevention and treatment of diseases of the skin.
(Arch Dermatol. 1991;127:1375-1382)
Kligman AM. The Invisible Dermatoses. Arch Dermatol. 1991;127(9):1375-1382. doi:10.1001/archderm.1991.01680080111013