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October 1991

Local Therapies for Cutaneous Kaposi's Sarcoma in Patients With Acquired Immunodeficiency Syndrome

Author Affiliations

The Johns Hopkins University, Baltimore, Md

Arch Dermatol. 1991;127(10):1479-1481. doi:10.1001/archderm.1991.01680090041004


Case 1.—  A 36-year-old man positive for the human immunodeficiency virus with biopsy-proven cutaneous Kaposi's sarcoma (KS) was referred for local treatment of his tumors. He had received radiation therapy 11 months earlier for lesions on his wrist, face, leg, and penis, with resultant flattening of the lesions; an eyelid lesion recurred 6 months after radiation therapy. In July, several typical KS lesions on his trunk and extremities were each treated with two freezethaw cycles of liquid nitrogen, administered as cryospray for 30 to 45 seconds in each cycle. He tolerated the procedure well. His skin did not blister. Examination 4 weeks later showed flattening of the lesions as well as diminution of the violaceous coloration. Pretreatment and posttreatment photographs are shown in Figs 1 and 2.

Case 2.—  A 48-year-old man with the acquired immunodeficiency syndrome (AIDS) and biopsy-proven cutaneous KS was referred for local

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