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November 1991

Regression of Scleromyxedema With Topical Betamethasone and Dimethyl Sulfoxide: A 30-Month Follow-up

Author Affiliations

Department of Dermatology Centre Hospitalier Universitaire Dupuytren 2 Avenue Alexis Carrel 87042 Limoges Cedex, France

Arch Dermatol. 1991;127(11):1733-1734. doi:10.1001/archderm.1991.01680100137029

To the Editor.—  Scleromyxedema is the generalized variant of papular mucinosis. It is commonly associated with a benign monoclonal immunoglobulin, and it may be associated with systemic manifestations.2 Topical therapy is usually ineffective, and various systemic treatments have been tried. Dramatic responses have been reported with therapy with antimetabolites, but serious side effects and deaths have occurred; these events have led to the search for newer approaches. We report the regression of cutaneous signs with the combination therapy of topical betamethasone and dimethyl sulfoxide that was followed up over 30 months.

Report of a Case.—  A 66-year-old white man first observed gradual infiltration of the skin of his face, hands, and feet in December 1986. He presented with waxy infiltration of the hands, forearms, elbows, face, upper trunk, and thighs and lichenoid papules of the abdomen and buttocks. A biopsy specimen showed split and fragmented collagen bundles interspersed

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