To the Editor.—
Granulomatous slack skin (GSS), an infrequent disorder characterized by progressively pendulous skin folds in flexural areas,1-4 has been considered autoimmune or inflammatory.2,3 Some cases have been associated with Hodgkin's disease.2 A histologic aspect similar to mycosis fungoides has been reported,1,5 which suggests that GSS could be a special variety of cutaneous T-cell lymphoma. Immunophenotype studies5 and clonal rearrangement of the T-cell β-receptor gene4 have shown the lymphoproliferative nature of this disease.
Report of a Case.—
In June 1989, a 66-year-old man presented with a submammary tumor that became enlarged during the previous 3 years. He had appreciable hyperpigmentation on the lumbosacral region and on the lower limbs. Later, a left supraclavicular nodule and night fever developed.The findings from the clinical examination revealed generalized poikiloderma and hyperpigmentation, a bulky fold under the left armpit, and pendulous indurated skin formations in the
Puig S, Iranzo P, Palou J, Martí R, Estrach T, Mascaró JM. Lymphoproliferative Nature of Granulomatous Slack Skin: Clonal Rearrangement of the T-cell Receptor ß-Gene. Arch Dermatol. 1992;128(4):562-563. doi:10.1001/archderm.1992.01680140146024