• Background and Design.—
Autoeczematization, the symmetric diffuse spread of a previously localized dermatitis, has an unclear etiology although some investigators have postulated that activated T lymphocytes play a role. Two estimates of activation of peripheral T lymphocytes are the cell surface expression of the HLA-DR antigen and the interleukin 2 receptor (IL-2R). We measured the percentage of circulating activated T lymphocytes in nine patients with autoeczematization compared with normal controls (n=10), patients with stasis dermatitis (n=6), and patients with severe (n=10) or mild (n=8) psoriasis. The percentage of activated T lymphocytes was determined by fluorescent, activated cell sorter analysis of peripheral leukocytes doubly stained with antibodies to T lymphocytes and HLA-DR antigen or IL-2R.
Statistically significant elevations of HLA-DR- and IL-2R-positive T lymphocytes were seen in autoeczematization patients (P<.004 and P<.04, respectively) and those with severe psoriasis (P<.004 for HLA-DR antigen and IL-2R). Percentages of HLA-DR- and IL-2R-positive T lymphocytes in patients with mild psoriasis were not significantly elevated. Two patients with autoeczematization had a reduction of their previously elevated levels of HLA-DR- and IL-2R-positive T lymphocytes after treatment.
These data suggest a possible role for circulating activated T lymphocytes in the pathogenesis of autoeczematization and possibly in severe psoriasis.(Arch Dermatol. 1992;128:795-798)
Kasteler JS, Petersen MJ, Vance JE, Zone JJ. Circulating Activated T Lymphocytes in Autoeczematization. Arch Dermatol. 1992;128(6):795-798. doi:10.1001/archderm.1992.01680160079008