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August 1992

Successful Therapy of Metastatic Eccrine Poroma Using Perilesional Interferon Alfa and Interleukin 2

Author Affiliations

Department of Dermatology University of Würzburg Medical School D-8700 Würzburg, Germany; Department of Dermatology University of Zurich Medical School CH-8091 Zurich, Switzerland

Arch Dermatol. 1992;128(8):1127-1128. doi:10.1001/archderm.1992.01680180123020

To the Editor.—  Eccrine sweat gland carcinomas represent a diversified group of rare and morphologically heterogeneous neoplasms of skin eccrine sweat glands that display some potential for distant metastasis.1-3 Due to an extraordinary degree of clinical and histopathologic variation,3 the identification of these tumors is, at times, difficult.Surgery is the main therapeutic procedure. Chemotherapy or radiotherapy are alternative treatments for metastatic disease.4,5 However, their therapeutic potential remains questionable.4,5 We report the successful treatment of multiple cutaneous metastases of a malignant eccrine poroma using interferon alfa in combination with interleukin 2.

Report of a Case.—  A 74-year-old white man was admitted to the hospital because of an 18-month history of an ulcerating tumor on his left fifth finger. Physical examination revealed an oval, 4×2.5-cm, foul-smelling ulcer. Several erythematous nodules were noted on the palmar surface of the left fifth finger and volar

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