Lipoprotein—T-cell interactions are being reported with increasing frequency, and there is evidence that lipoproteins play a role in immunoregulation. We describe a patient with mycosis fungoides and hyperlipidemia who developed xanthomatization in one preexisting plaque. The case is unique in that some of the lipidized cells were atypical T cells. In previously reported cases of mycosis fungoides with dystrophic xanthomatosis, the lipid-containing cells have been identified only as histiocytes.
Immunopathologic feautures, electron microscopy, and lipid stains of the xanthomatized plaque demonstrated that some of the lipid-laden cells were atypical T cells.
In mycosis fungoides, malignant T cells may be intimately involved in processing of tissue lipids. We suggest that low-density lipoprotein receptors on activated T cells facilitated the cytoplasmic lipidization in this case.(Arch Dermatol. 1992;128:1499-1502)
Ross EV, Roman L, Rushin JM, Cobb MW, Friedman KJ. Xanthomatized Atypical T Cells in a Patient With Mycosis Fungoides and Hyperlipidemia. Arch Dermatol. 1992;128(11):1499-1502. doi:10.1001/archderm.1992.01680210077011