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December 1992

Extracorporeal Photochemotherapy as Adjunctive Treatment in Juvenile Dermatomyositis: A Case Report

Author Affiliations

Department of Internal Medicine Morristown Memorial Hosptial 100 Madison Ave Morristown, NJ 07960

Department of Pediatrics University of Southern California School of Medicne 2025 Zonal Ave Los Angeles, CA 90033

Department of Internal Medicine Morristown Memorial Hosptial 100 Madison Ave Morristown, NJ 07960

Photopheresis Unit Morristown Memorial Hospital 100 Madison Ave Morristown, NJ 07960

Arch Dermatol. 1992;128(12):1656-1657. doi:10.1001/archderm.1992.04530010092025

To the Editor.  —Juvenile dermatomyositis (JDMS) is an inflammatory myopathy characterized by a classic heliotrope rash, proximal muscle weakness, and elevated muscle enzyme levels. Autoimmunity, both humoral and cellular, is implicated in the pathogenesis. High doses of steroids and agMonths After Start of PhotopheresisPatient's enzyme studies throughout the course of combined therapy with methotrexate and photopheresis. ALT indicates alanine aminotransferase; AST, aspartate aminotransferase[ill] and ULN, upper limit of normal. gressive physical therapy are the mainstay of treatment. In patients unresponsive to or intolerant of steroid [ill] therapeutic modalities such as methotrexate, cytotoxic drugs, total body irradiation, and plasmapheresis are used.1 Extracorporeal photochemotherapy has been reported for the treatment of autoimmune diseases.2,3 We describe a patient with JDMS whose disease progressed on treatment with methotrexate alone and who appears to respond to adjunctive therapy with extracorporeal photopheresis.

Report of a Case  .—Our patient, an 18-year-old woman, developed

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