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Article
January 1993

Solitary Congenital Indeterminate Cell Histiocytoma

Author Affiliations

From the Departments of Dermatology (Drs Levisohn, Seidel, and Burgdorf) and Pathology (Dr Phelps), University of New Mexico School of Medicine, Albuquerque.

Arch Dermatol. 1993;129(1):81-85. doi:10.1001/archderm.1993.01680220093021
Abstract

• Background.—  Indeterminate cell proliferations are rarely described in the literature. We present a case of a patient who presented at birth with a solitary lesion that spontaneously regressed.

Observations.—  Five cases of indeterminate cell proliferations have been described in the literature. Their clinical patterns display some common features including adult onset, usually with multiple lesions and a relatively benign clinical course. This patient presented at birth with a single lesion and spontaneous regression, as one would expect with congenital self-healing reticulohistiocytosis. Biopsy confirmed a dermal histiocytic nodule that was predominantly CD1 and S100 positive. Unlike patients with congenital self-healing reticulohistiocytosis, however, electron microscopy failed to demonstrate Birbeck granules.

Conclusion.—  Indeterminate cell proliferations are a distinct entity. This presentation expands the range of clinical manifestations reported. It also suggests a close relationship between indeterminate cells and Langerhans cells.(Arch Dermatol. 1993;129:81-85)

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