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January 1993

Lymphomatoid Papulosis Followed by Hodgkin's LymphomaDifferential Response to Therapy

Author Affiliations

From the Departments of Dermatology (Drs Zackheim, LeBoit, and Gordon), Pathology (Dr LeBoit), University of California, San Francisco, and Mt Zion Medical Center, San Francisco, Calif (Dr Glassberg).

Arch Dermatol. 1993;129(1):86-91. doi:10.1001/archderm.1993.01680220098022

• Background.—  The association of lymphomatoid papulosis (LyP) with Hodgkin's lymphoma or other lymphomas is well recognized. However, the issue as to whether this represents an independent association or a transformation of one proliferative process to the other remains unresolved.

Observation.—  A woman with LyP subsequently developed Hodgkin's lymphoma. Combination chemotherapy resulted in apparent cure of the lymphoma but had only a transient effect on the LyP. A literature review revealed a similar difference in response to chemotherapy or radiation therapy in most patients who had LyP and associated lymphoma.

Conclusions.—  The differential response to therapy in patients with LyP and associated lymphoma suggests that there are biological differences between LyP cells and associated lymphoma cells even though in some patients the immunophenotype and genotype were reported to be identical. However, alternative explanations are possible. In this article we also review studies on other cases of LyP associated with Hodgkin's lymphoma.(Arch Dermatol. 1993;129:86-91)