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Article
February 1993

Epidermal Hyperplasia With or Without Atypia in Patients Exposed to Mustard Gas

Author Affiliations

Department of Dermatopathology University of Liège School of Medicine CHU du Sart Tilman B-4000 Liège, Belgium; Center for Research and Training and Skin Diseases Tehran,Iran 14166

Arch Dermatol. 1993;129(2):245. doi:10.1001/archderm.1993.01680230135021
Abstract

To the Editor.—  We would like to comment on several aspects of the article "Skin Manifestations of Mustard Gas"1 that appeared in the June 1992 issue of the Archives. We have examined seven biopsy specimens of victims exposed to mustard gas during the Iran-Iraq war.2 A biopsy specimen was obtained from one lesion in an early stage of blistering; five lesions corresponded to xerodermoid-type lesions. The seventh patient had a persistent oozing plaque on the penis for a few months. Our histopathologic findings correlate with those of Momeni et al.1 However, the authors have failed to mention important signs of epidermal hyperplasia with or without atypia. We have found many binucleated keratinocytes and even bowenoid changes. By morphometric analysis, the profile area of a bowenoid nuclei reached twice that of apparently normal nuclei of the stratum malpighii. Melanocytes with severely atypical nuclei and vacuolated cytoplasm were also

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