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March 1993

Systemic Dapsone

Arch Dermatol. 1993;129(3):301-303. doi:10.1001/archderm.1993.01680240041004


Leprosy (treatment):  Dapsone is indicated in combination with other antileprosy agents in the treatment of all types of leprosy (Hansen's disease) caused by Mycobacterium leprae

Dermatitis herpetiformis (treatment):  Dapsone is indicated in the treatment of dermatitis herpetiformis

Cicatricial pemphigoid (treatment):  Dapsone is used in the treatment of desquamative gingival lesions caused by cicatricial pemphigoid*

Dermatitis herpetiformis suppressant:  Mechanism is unknown, but not due to dapsone's bacteriostatic effects. Dapsone may act as an enzyme inhibitor or oxidizing agent. In addition, it has numerous immunologic effects (eg, immunosuppression, which most likely accounts for its suppression of dermatitis herpetiformis)*

Dermatosis, subcorneal pustular (treatment):  Dapsone is used in the treatment of subcorneal pustular dermatosis*

Granuloma annulare (treatment):  Dapsone is used in the treatment of granuloma annulare*

Lupus erythematosus, systemic (treatment):  Dapsone is used in the treatment of certain skin lesions of systemic lupus erythematosus, including bullous eruptions and urticarial vasculitis*

Pemphigoid (treatment): 

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