[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.163.159.27. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
March 1993

Porphyria Cutanea Tarda in the Setting of Renal FailureResponse to Renal Transplantation

Author Affiliations

From the Departments of Dermatology (Dr Crosby) and Medicine (Drs Stevens and Piering), Medical College of Wisconsin, Milwaukee; and Department of Dermatology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC (Dr Fleischer).

Arch Dermatol. 1993;129(3):337-339. doi:10.1001/archderm.1993.01680240077010
Abstract

• Background.—  Porphyria cutanea tarda (PCT) and similar vesiculobullous disorders have been described with increased frequency in patients with chronic renal failure undergoing long-term hemodialysis. Descriptions of over 20 cases of hemodialysis-related PCT have appeared in the literature. The precise cause of PCT in chronic renal failure is unknown, and the treatment of PCT occurring in this setting is complex and often ineffective.

Observations.—  We describe a patient who developed hemodialysis-related PCT, which, in this patient, was refractory to various treatment modalities. This patient eventually went on to receive a renal transplant and all symptoms of PCT resolved with normalization of urinary porphyrin levels.

Conclusions.—  We propose that in PCT refractory to the currently available treatment modalities occurring after the development of chronic renal failure, renal transplantation is indicated as a potentially efficacious therapy.(Arch Dermatol. 1993;129:337-339)

×