In the January 1993 issue of the Archives, Zackheim et al1 described an interesting patient with a 7-year history of lymphomatoid papulosis (LyP) who developed nodular sclerosing Hodgkin's disease (HD). This case report and review of the literature of LyP-associated lymphomas raise several important theoretical and practical questions regarding the nature of LyP and its relationship to malignant lymphomas. (1) Are the lesions of LyP and malignant lymphoma independent or directly related? (2) Does LyP transform into a malignant lymphoma? (3) What is the pathogenesis of LyP? (4) What is the appropriate clinical management of patients with LyP?
Review of the case reported by Zacheim is revealing. The patient initially developed HD in an axillary lymph node after a 7-year history of a recurrent eruption of LyP papules, mostly on the extremities. Before the development of lymphadenopathy, the patient had a mild leukocytosis, which included Sézary-type lymphoid cells.
Kadin ME. Lymphomatoid Papulosis and Associated LymphomasHow Are They Related?. Arch Dermatol. 1993;129(3):351-353. doi:10.1001/archderm.1993.01680240091015