To the Editor.—
Human papillomavirus (HPV), an established causative organism of viral warts, has recently been isolated from several mucocutaneous tumors with differing clinical features. This finding suggests that HPV could also be involved in other skin conditions. Indeed, several articles describing HPV-related epidermoid cysts have recently appeared.1-3 However, the true pathomechanism of the cysts is still unknown. We report a case of multiple plantar warts with inverted growth, one of which was invaginated into the underlying dermis and resulted in a semicystic histologic feature.
Report of a Case.—
A 23-year-old man visited our clinic because of multiple plantar warts of 2 months' duration. Three months before onset, he had suffered injuries that left iron filings at the site where the plantar warts subsequently developed. During the clinical course, a subcutaneous tumor with tenderness developed beneath one of the warts. The verrucous lesions were excised with a scalpel while he was receiving local anesthesia. The clinical examination revealed several verrucous lesions on the right sole; a subcutaneous nodule was
Egawa K, Hayashibara T, Ono T. Inverted Plantar Wart. Arch Dermatol. 1993;129(3):385-386. doi:10.1001/archderm.1993.01680240131028