Blue-gray pigmentation of the skin can be elicited by several medications. We report the first case (to our knowledge) of desipramine-induced photosensitive blue-gray pigmentation.
Diffuse blue-gray pigmentation on sun-exposed surfaces was noted in a healthy 48-year-old woman who had been taking desipramine hydrochloride for 8 years. Ultrastructural studies demonstrated the presence of melanin and homogeneous electron-dense material in the dermis.
We conclude that tricyclic antidepressant agents represent another class of medications responsible for blue-gray cutaneous pigmentation.(Arch Dermatol. 1993;129:474-476)
Narurkar V, Smoller BR, Hu C, Bauer EA. Desipramine-Induced Blue-Gray Photosensitive Pigmentation. Arch Dermatol. 1993;129(4):474-476. doi:10.1001/archderm.1993.01680250086012