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Article
April 1993

Hemorrhagic Darier's Disease

Author Affiliations

Department of Dermatology PO Box 697 University of Rochester School of Medicine and Dentistry 601 Elmwood Ave Rochester, NY 14642; Olean Medical Group 535 Main St Olean, NY 14760

Arch Dermatol. 1993;129(4):511-512. doi:10.1001/archderm.1993.01680250127024
Abstract

To the Editor.—  While examining 34 individuals with Darier's disease from three large pedigrees in the southern tier of New York State, we found five individuals, all from one pedigree (DD-He) who had hemorrhagic bullae and red and black macules with jagged borders on the hands and feet (Figs 1 and 2). The lesions developed after trauma and would resolve after several weeks. There was no history of hemorrhagic lesions in anyone in the kindred who did not have Darier's disease. The age of onset of Darier's disease was no different for individuals with or without hemorrhagic lesions. Some members of pedigree DD-He had been reported previously by Beck et al.1Hemorrhagic Darier's disease was first described in 1964 by Jones et al2 in four patients with Darier's disease, two of whom were a mother and daughter. Biopsy specimens from these patients showed intraepidermal lacunae filled with red

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