Sweet's been reported to occur in association with several conditions.1-5 The most important one is malignancy, with an estimated incidence of 10% to 15%.3 We report the first description of concurrent Sweet's syndrome and acute sarcoidosis in three patients (Table) and emphasize that this could be an alternative diagnosis to malignancy in patients with Sweet's syndrome who present with lymphadenopathy.
Report of Cases
A 35-year-old white woman presented with a temperature of 39.6°C, synovitis of her knees and ankles, and skin lesions resembling erythema nodosum. Subsequently, distinct painful erythematous elevated plaques developed. The biopsy specimen was consistent with Sweet's syndrome. The chest roentgenogram and a thoracic computed tomographic scan demonstrated mediastinal lymph nodes bilaterally. The tuberculin skin test was negative. Sarcoidosis was considered, but the biopsy specimen of the minor salivary gland and a bronchus and the bronchoalveolar lavage showed normal findings. Because of the potential association
Pouchot J, Bourgeois-Droin C, Vinceneu P, Barge J, Brun P, Granier F, Trémolières F. Sweet's Syndrome and Mediastinal Lymphadenopathy due to Sarcoidosis: Three Cases of a New Association. Arch Dermatol. 1993;129(8):1062-1064. doi:10.1001/archderm.1993.01680290138029