Background and Design:
Giant aggressive keratoacanthoma is a rare destructive subset of keratoacanthoma that frequently involves the facial region, grows rapidly to a large size, and often recurs after surgical management. The effectiveness of ionizing radiation therapy was examined in a retrospective study involving 16 patients; 14 of the tumors had recurred after surgical therapy.
All tumors resolved with satisfactory cosmetic results and without recurrence following a fractionated course of superficial radiation therapy.
Radiation therapy is an effective therapeutic modality for giant aggressive keratoacanthomas.(Arch Dermatol. 1993;129:1162-1165)
Goldschmidt H, Sherwin WK. Radiation Therapy of Giant Aggressive Keratoacanthomas. Arch Dermatol. 1993;129(9):1162-1165. doi:10.1001/archderm.1993.01680300090014