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September 1993

Antibodies Inside Our Keratinocytes?

Author Affiliations

Department of Dermatology University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas, TX 75235-9069

Arch Dermatol. 1993;129(9):1184-1187. doi:10.1001/archderm.1993.01680300112019

THE FINDINGS reported by Ioannides and Bystryn1 in this issue of the Archives are enough to not only cause Paul Ehrlich (auto horrortoxicus) to roll over in his grave but also to spark a twinkle in Stephen King's eye. The studies presented by these authors further the notion that not only is our immune system able to produce antibodies directed against antigens normally associated with our own keratinocytes, but that these autoantibodies actually have the capability of penetrating into our living keratinocytes in vivo without producing overt clinical disease and establishing some form of gruesome symbiotic relationship with the internal components of our own cells. These authors along with others who have previously dealt with this and related issues have presented such suggestions with the calm detachment typical of true scientists; however, it might be worthwhile at this point to mull over the ramifications of such extraordinary claims.


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