Among the clinical entities felt to result from biologically active agents produced by neoplasms is the proliferative skin disorder of Leser-Trélat. This syndrome is characterized by the rapid emergence of multiple seborrheic keratoses in association with an internal malignancy. Though traditionally associated with adenocarcinomas of the stomach, hematopoietic malignancies are the second most recorded neoplasm to be linked with the sign of Leser-Trélat.1 Moreover, there have been several specific cases in patients with mycosis fungoides and Sézary syndrome.2-4
In this report, we document an additional case of multiple seborrheic keratoses paralleling the evolution of Sézary syndrome and its response to a new combination treatment with interferon alfa and extracorporeal photopheresis.5 Our observation of the resolution of the sign of Leser-Trélat in concert with the induction of a complete remission of the cutaneous T-cell lymphoma, which is documented at the clinical and molecular level, is discussed.
Cohen JH, Lessin SR, Vowels BR, Benoit B, Witmer WK, Rook AH. The Sign of Leser-Trélat in Association With Sézary Syndrome: Simultaneous Disappearance of Seborrheic Keratoses and Malignant T-Cell Clone During Combined Therapy With Photopheresis and Interferon Alfa. Arch Dermatol. 1993;129(9):1213-1215. doi:10.1001/archderm.1993.01680300143034