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October 1993

Pityriasis Rubra Pilaris and Cyclosporine

Author Affiliations

Southern California Dermatology and Psoriasis Center 2001 Santa Monica Blvd Suite 490W Santa Monica, CA 90404-2115

Arch Dermatol. 1993;129(10):1346-1348. doi:10.1001/archderm.1993.01680310118029

Pityriasis rubra pilaris (PRP) has been classified into five subtypes by Griffiths.1 Type I, classic adult PRP, is the most common subtype, representing over 50% of cases. Systemic retinoids (etretinate and isotretinoin) and antimetabolites (methotrexate and azathioprine) are effective treatments of PRP.2 The use of cyclosporine for treatment of PRP was first discussed in 1989.3 We present a case of successful treatment of adult-onset PRP with lose-dose cyclosporine. Complete clearance of PRP was achieved with no recurrence for over 2 years.

Report of a Case.  A 60-year-old white woman was evaluated by her primary dermatologist for a 1-month history of a pruritic facial rash. A preliminary diagnosis of facial dermatitis led to treatment with oral prednisone (80 mg/ d). However, the facial rash worsened, and the palms soon appeared yellowish and thickened. Within 2 months of onset, a widespread eruption of pruritic erythematous plaques appeared over much

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