[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.146.176.30. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
November 1993

The Morbid Cutaneous Anatomy of the Human Genome

Author Affiliations

From the Department of Dermatology, University of California Medical Center, San Francisco.

Arch Dermatol. 1993;129(11):1417-1423. doi:10.1001/archderm.1993.01680320051007
Abstract

Background:  The identification of genes whose mutations underlie hereditary diseases has long been a holy grail and one whose satisfaction very recently has become a reality for a surprisingly large number of dermatologic diseases.

Observations:  This review summarizes in brief the chromosomal localization and, where known, the gene identification for diseases expressed primarily in the skin. These vary from skin cancer genes whose products control cell growth and carry out DNA repair to skin fragility genes whose products impart mechanical stability to the skin.

Conclusions:  The explosion of new data in the past several years summarized herein is nearly unprecedented and bodes well for the development of new therapeutic approaches to common as well as rare skin disorders.(Arch Dermatol. 1993;129:1417-1423)VICTOR A. McKusick, MD, published a series of review articles from 1986 through 1988, entitled "The Morbid Anatomy of the Human Genome."1-4 By this title, he indicated that

First Page Preview View Large
First page PDF preview
First page PDF preview
×