Adverse cutaneous reactions to novel drugs should rapidly be brought to the attention of dermatologists. Acute photosensitivity after ingestion of a new, once-a-day oral fluoroquinolone antibiotic, lomefloxacin hydrochloride (Maxaquin), and exposure to winter sunlight is reported herein.
Report of a Case.
A 25-year-old woman went skiing in New England over a 3-day weekend in February, leaving only the central portion of her face uncovered while on the slopes. On the evening of the third day, this area became fiery red and painful. During the next 2 days, her nose exuded serous fluid that dried into a thick yellowish crust, and her lower lip vesiculated. She denied previous exaggerated sunburns or other photosensitivity problems, allergies of any kind, use of facial cosmetics or sunscreens during the weekend, and all medications except birth control pills. Since photosensitization by an exogenous agent was strongly suspected on clinical grounds, her drug history was reexplored.
Poh-Fitzpatrick MB. Lomefloxacin Photosensitivity. Arch Dermatol. 1994;130(2):261. doi:10.1001/archderm.1994.01690020131031