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April 1994

Painful Plantar Callouses and Mental Retardation

Author Affiliations

Hospital Insular, Las Palmas de Gran Canaria, Spain

Arch Dermatol. 1994;130(4):509-510. doi:10.1001/archderm.1994.01690040115019

REPORT OF A CASE  During his adolescence, a 54-year-old man began to complain of painful callouses on his soles. During all these years, the lesions improved or worsened spontaneously, although they never disappeared completely. Treatment with keratolytic ointments was ineffective. Occasionally, the lesions had been so painful that they prevented him from walking. On presentation, he walked with crutches to minimize pressure over his painful callouses.He had mild mental retardation. He was the second of four siblings born of a consanguineous marriage. The family history showed that one of his uncles also suffered from the same disease. On physical examination, the only cutaneous lesions were a few well-circumscribed hyperkeratotic plaques on both soles, limited to weight-bearing areas (the heels and the first and fifth heads of the metatarsal bones) (Figure 1 and Figure 2). Light pressure over his callouses elicited intense pain. His palms were unaffected, and his hair,

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