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April 1994

Staphylococcus aureus Carriage and HIV-1 Disease: Association With Increased Mucocutaneous Infections as well as Deep Soft-Tissue Infections and Sepsis

Author Affiliations

USA Walter Reed Army Institute of Research Washington, DC 20307

Bethesda, Md

USN Washington, DC

USN Washington, DC

Bethesda, Md 20889

Arch Dermatol. 1994;130(4):521-522. doi:10.1001/archderm.1994.01690040129026

Cutaneous colonization by Staphylococcus aureus has been found to be significantly increased in patients infected with the human immunodeficiency virus (HIV-1). The incidence of S aureus carriage was shown to stay relatively constant with disease progression, Walter Reed (WR) stage 1 through 6.1

Staphylococcus aureus sepsis, deep soft-tissue infections, and pneumonia have all been frequently reported in patients with advancing HIV-1 disease, and S aureus infections, often undiagnosed premortem, were seen in greater than 50% of the patients from one autopsy study.2 Trauma, intravenous catheters (peripheral and central lines), intravenous drug abuse, and lymphedema are considered to be risk factors. As part of a study on the natural history of cutaneous disease in HIV-1 disease, patients were followed up prospectively to determine if there was a correlation with infection by S aureus and the stage of disease.

Patients and Methods.  A total of 646 HIV-1—positive patients were

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