Bataille et al1 in their article in the February 1993 issue of the Archives point out the importance of a thorough dermatologic examination in patients with ocular melanomas. A statistically significant increase in the number of cutaneous melanomas was found, and the authors rightly conclude that the ''coexistence of ocular and cutaneous melanomas suggests a predisposition to both in some family cancer syndromes, particularly AMS [atypical mole syndrome].''
In 19802,3 we reported the first patient to have both a primary and an ocular melanoma occurring simultaneously. At that time, an association between ocular and cutaneous melanomas was suggested in patients with the familial form of AMS, and it was hypothesized that these patients had a greater predisposition to have ocular melanomas develop, perhaps based on a single gene transmitting both the ocular and the cutaneous tumors. The study shifted to ocular nevi because of the rarity of ocular
Rodriguez-Sains RS. Coexistent Primary Ocular and Cutaneous Melanoma. Arch Dermatol. 1994;130(5):660. doi:10.1001/archderm.1994.01690050130023