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Article
May 1994

Treatment of Severe Forms of Localized Scleroderma With Oral Corticosteroids: Follow-up Study on 17 Patients

Author Affiliations

Department of Dermatology Hôpital Charles Nicolle 1 rue de Germont 76031 Rouen Cedex, France

Arch Dermatol. 1994;130(5):663-664. doi:10.1001/archderm.1994.01690050133027
Abstract

Despite the lack of visceral involvement, localized scleroderma (LS) may be responsible for severe deformities and functional disabilities.1 No drug has been proven to be effective in the treatment of LS.1-4 In the present study, 17 patients with the most severe forms of LS were treated with oral corticosteroids in an open trial during a 10-year follow-up period in an attempt to assess the influence of oral corticosteroids on the course of LS.

The inclusion criteria were the following: (1) the disease was severe and disabling and included facial scleroderma (en coup de sabre) in seven patients, linear scleroderma in five patients, and rapidly occurring generalized morpheas in five patients; (2) the diagnosis of scleroderma was established clinically and confirmed by skin biopsy specimen in 13 patients; (3) the absence of signs of progressive systemic scleroderma5 (in particular, no patient had visceral involvement); (4) treatment consisted of oral

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