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May 1994

Porphyria Cutanea Tarda in Association With Human Immunodeficiency Virus Infection: Is It Related to Hepatitis C Virus Infection?

Author Affiliations

University of Nice 06107 Nice Cedex 2, France

Nice, France

Arch Dermatol. 1994;130(5):664-665. doi:10.1001/archderm.1994.01690050134028

Several authors have reported the onset of porphyria cutanea tarda (PCT) in human immunodeficiency virus (HIV)—infected patients.1-3 We and other authors4,5 have shown a strong association between PCT and hepatitis C virus (HCV). As HIV and HCV infections have common risk factors, especially blood transfusion and intravenous drug abuse, HIV-associated PCT might be also related to HCV.

In 1990, we examined a 30-year-old man who had a history of intravenous drug use and was documented as being positive for antibody to HIV since 1987. He had no symptoms related to immunodeficiency or liver disease. He had typical skin manifestations of PCT, which was confirmed by an elevated urinary porphyrin level. Liver function test results were as follows: alanine aminotransferase, 85 U/L (normal, 5 to 40 U/L); aspartate aminotransferase, 53 U/L (normal, 5 to 30 U/L); γ-glutamyl transpeptidase, 93 U/L (normal, 7 to 33 U/L); and alkaline phosphatase, 62

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