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Article
September 1994

Hailey-Hailey DiseaseEradication by Dermabrasion

Author Affiliations

From the Departments of Dermatology, Universities of Münster (Drs Hamm and Metze) and Würzburg (Drs Hamm and Bröcker), Germany.

Arch Dermatol. 1994;130(9):1143-1149. doi:10.1001/archderm.1994.01690090067009
Abstract

Background:  Chronic benign familial pemphigus (Hailey-Hailey disease) is a rare dominant genodermatosis that bothers patients by chronic recalcitrant plaques occuring mainly in the intertriginous areas. We looked for a surgical treatment that is not impaired by the complications and disadvantages of radical excision and grafting of involved areas. In 10 patients with debilitating Hailey-Hailey disease (five men, five women; age, 36 to 57 years), nine different involved areas (neck, axilla, cubital area, inframammary area, periumbilical area, groin and adjacent inner thigh, scrotum, vulva, and the perineal/perianal area) were treated by dermabrasion for a total of 46 treated regions. The plane of abrasion was located in the upper to middle dermis as verified by random sampling before and after surgery, thus documenting removal of the entire epidermis.

Results:  In most instances, reepithelialization was completed after 7 to 10 days followed by excellent functional and cosmetic long-term results. When examined 3 to

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