Neonatal lupus erythematosus (NLE) is characterized by annular erythema on the face of infants born to mothers who have antibodies to SS-A/Ro and SS-B/La.1 Patients with NLE often have associated congenital heart block and a variety of hematologic and systemic abnormalities. It is thought that these clinical symptoms are induced by a reaction between the maternal autoantibodies transferred to the affected infants and the corresponding antigens.1 We report for the first time two sisters with NLE who subsequently developed hydrocephalus a few weeks after the onset of the skin lesion. We believe that hydrocephalus should be included in one of the clinical symptoms related to NLE.
Report of Cases.Case 1.
A 4-week-old girl was referred to our clinic because of annular erythema of 1 week's duration. The baby was born to a 32-year-old mother at a birth weight of 2688 g after a full-term, uneventful pregnancy. The
Nakayama-Furukawa F, Takigawa M, Iwatsuki K, Sato N, Sato H. Hydrocephalus in Two Female Siblings With Neonatal Lupus Erythematosus. Arch Dermatol. 1994;130(9):1210-1212. doi:10.1001/archderm.1994.01690090144029