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Article
September 1994

Hydrocephalus in Two Female Siblings With Neonatal Lupus Erythematosus

Author Affiliations

Hamamatsu, Japan

Department of Dermatology Fukushima Medical College Hikarigaoka 1 Fukushima 960-12, Japan

Shizuoka, Japan

Arch Dermatol. 1994;130(9):1210-1212. doi:10.1001/archderm.1994.01690090144029
Abstract

Neonatal lupus erythematosus (NLE) is characterized by annular erythema on the face of infants born to mothers who have antibodies to SS-A/Ro and SS-B/La.1 Patients with NLE often have associated congenital heart block and a variety of hematologic and systemic abnormalities. It is thought that these clinical symptoms are induced by a reaction between the maternal autoantibodies transferred to the affected infants and the corresponding antigens.1 We report for the first time two sisters with NLE who subsequently developed hydrocephalus a few weeks after the onset of the skin lesion. We believe that hydrocephalus should be included in one of the clinical symptoms related to NLE.

Report of Cases.Case 1.  A 4-week-old girl was referred to our clinic because of annular erythema of 1 week's duration. The baby was born to a 32-year-old mother at a birth weight of 2688 g after a full-term, uneventful pregnancy. The

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