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November 1994

Carbon Dioxide Laser Vaporization Combined With Perilesionally Injected Interferon Alfa-2b in the Treatment of a Hyperkeratotic Verruca Vulgaris on the Upper Eyelid

Author Affiliations

Gentofte Hospital, Copenhagen, Denmark

Arch Dermatol. 1994;130(11):1369-1370. doi:10.1001/archderm.1994.01690110031003

REPORT OF A CASE  A 50-year-old, otherwise healthy man was referred to our clinic with a large hyperkeratotic tumor covering the left upper eyelid (Figure 1, A and B). The lesion had been present for more than a decade, and its size slowly increased. The lesion was cosmetically unacceptable, and, due to the weight of the tumor, our patient could hardly open his eye. Two separate deep biopsy specimens were obtained for histologic examination. Both specimens showed a benign histologic appearance with acanthosis, papillomatosis, and hyperparakeratosis. Koilocytic epidermal cells were present in the middle and upper epidermal layer (Figure 2).

THERAPEUTIC CHALLENGE  Both the plastic surgeon and the ophthalmologist were unwilling to perform surgical excision and grafting due to the risk of cicatricial shrinking of the upper eyelid. Lo

Figure 1.  Hyperkeratotic verruca vulgaris on the upper eyelid before (A and B) and after (C and D) treatment with carbon

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