Porphyria cutanea tarda (PCT), the most common porphyria, may be sporadic or inherited as an autosomal dominant trait and is characterized by decreased activity of the enzyme uroporphyrinogen decarboxylase. Porphyria cutanea tarda may be induced by environmental factors (alcohol, estrogens, iron, and polyhalogenated aromatic hydrocarbons). Associations of PCT with hepatitis B,1,2 hepatitis C,3,4 and human immunodeficiency virus have been reported. We describe an unusual coincidence of PCT in a married couple.
Report of Cases.
Our patients are a nonconsanguineous husband and wife with similar clinical presentations and porphyrin profiles.A 36-year-old white woman and a 45-year-old white man presented with histories of skin fragility, increasing facial hair, darkening of urine, and blistering of light exposed skin. Neither had a history of hepatitis or of receiving blood transfusions; however, both had used intravenous drugs for 10 years prior to 1980, and had also intermittently ingested moderate-to-heavy amounts of alcohol
Alapati UR, Poh-Fitzpatrick MB. Conjugal Porphyria Cutanea Tarda. Arch Dermatol. 1995;131(1):111-112. doi:10.1001/archderm.1995.01690130115030