Dr.Klotz gave the history of a case of syphilis with unusual features. The patient was a man who presented himself at the dispensary with an indurated lesion on the prepuce, which he stated had made its appearance three or four weeks before. Some days later he returned and said that on the evening previous he had had high fever and an intense itching over the chest. On examination an eruption very similar to that of urticaria was found in this region; the lesions were reddish in color, and on top of each was a clear vesicle which did not cover the entire surface. These vesicles gradually become more numerous, and many of them dried up and formed a very thin scale in the center of the papule, which otherwise was soft and of a much lighter color than syphilitic papules usually are. They appeared exactly six weeks after infection. The speaker said he has never seen nor read of syphilitic lesions which appear as clear vesicles.
J Cutan Genito-Urin Dis. February 1895;13:78-79.
Report of Cases presented at Previous Meetings. Arch Dermatol. 1995;131(2):140. doi:10.1001/archderm.1995.01690140022003