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Article
February 1995

Pseudolymphoma?

Author Affiliations

Department of Dermatology University of Graz Auenbruggerplatz 8 A-8036 Graz, Austria

Arch Dermatol. 1995;131(2):226. doi:10.1001/archderm.1995.01690140112021
Abstract

We enjoyed reading the article1 ''Postzoster cutaneous pseudolymphoma'' by Roo et al,1 which appeared in the May 1994 issue of the Archives. We are not convinced of the diagnosis of ''pseudolymphoma'' proposed by the authors. Cutaneous lymphoid infiltrates in zoster scars are not uncommon in patients with B-cell chronic lymphocytic leukemia (B-CLL), and, in our experience, usually represent a specific infiltrate of leukemic cells. Similar features have been observed in colonization of zoster scars by lymphoplasmacytoid lymphoma.2 The clinical evolution does not differentiate leukemic skin infiltrates from benign inflammatory processes, as resolution of the lesions after local therapy may be observed in both. Also, the criteria used by Roo and coworkers for the histopathologic differential diagnosis between benign and malignant cutaneous lymphoid infiltrates are unsatisfactory when applied to patients with B-CLL. In fact, specific infiltrates of B-CLL usually present with a dense perivascular infiltrate in the superficial and

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