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February 1995


Author Affiliations

Department of Dermatology Hospital Universitario San Carlos Zurbano 25 28010 Madrid, Spain

Arch Dermatol. 1995;131(2):226. doi:10.1001/archderm.1995.01690140112022

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We appreciate the comments by Dr Cerroni concerning our article; we know of his expertise in the field of immunophenotyping of cutaneous lymphoproliferative disorders. The expression of some T-cell—associated antigens by B lymphocytes is a frequent and useful criterion to identify some B lymphocytes, both in frozen and in paraffin-embedded sections.

Let us supply some further histologic data. Our immunohistochemical studies were performed on paraffinembedded sections with the following antibodies: Mtl, UCHL1, L26, MB-2, and antiκ and antiλ light chains. More than 90% of lymphoid cells were positive for anti—T-cell antibodies (MT1 and UCHL1); less than 10% were positive forantiB-cell antibodies (126 and MB-2). Normal-appearing plasma cells, containing both κ and λ light chains, were scattered throughout the infiltrate, mainly in the periphery of the nodules. Histiocytic cells, not reactive with the above= mentioned antibodies, formed eccentrically situated groups within the nodules.

These data, and those previously mentioned, prompt us

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