We have read with interest the recent article by Magee et al1 regarding overexpression of p53 in the nuclei of (mainly basal) keratinocytes within or under the lamella cornoides (cornoid lamella) in the lesions of porokeratosis. The findings of Magee et al1 support the premalignant potential of porokeratosis lesions but are in contrast with the pattern of expression of p53 in Bowen's disease, in which intense staining is present in the middle and upper spinous layers, similar to that seen in solar keratosis.
Malignant degeneration has been observed in up to 10% of cases of porokeratosis, the most common types of lesions reported being in situ or invasive squamous cell carcinomas, Bowen's disease, and, rarely, basal cell carcinomas. We have attempted to confirm the results obtained by Magee et al using a different monoclonal antibody to assess p53 expression in keratinocytes from disseminated superficial actinic porokeratosis (DSAP) lesions and
Puig L, Alegre M, Costa I, Matías-Guiu X, Moragas JMD. Overexpression of p53 in Disseminated Superficial Actinic Porokeratosis With and Without Malignant Degeneration. Arch Dermatol. 1995;131(3):353-354. doi:10.1001/archderm.1995.01690150119025