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May 1995

Lupus Pernio: Successful Treatment With a Potent Topical Corticosteroid

Author Affiliations

Department of Dermatology University of California, Davis 1605 Alhambra Blvd Suite 2300 Sacramento, CA 95816-7051

Arch Dermatol. 1995;131(5):617-618. doi:10.1001/archderm.1995.01690170121026

Lupus pernio is a rare cutaneous manifestation of sarcoidosis.1 It was first described by Besnier in 1889,2 who proposed the name lupus pernio to describe a patient with multiple violaceous nodules of a chronic nature involving the face and extremities. It usually manifests itself as chronic, violaceous, nodules or plaques on the nose, cheeks, ears, and distal extremities.1 These lesions commonly result in considerable de formity, with fibrosis and scarring.3 The diagnosis of lupus pernio is made by typical clinical presentation and histopathologic finding of sarcoidal granuloma. Treatment of lupus pernio is aimed at preventing progression, promoting regression, or alleviating symptoms with the creation of minimal side effects.1 Corticosteroids remain the mainstay of treatment.

Report of a Case.  A 42-year-old African-American woman was referred to the dermatology clinic with a 3-year history of gradually enlarging and disfiguring papules on her nose and lower eyelids. Physical

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