We have followed a patient with human immunodeficiency virus (HIV) infection and erythrodermic cutaneous T-cell lymphoma (CTCL). He eventually developed tumor-stage disease and large numbers of circulating atypical helper T cells (Sézary's syndrome). He suffered progression of HIV disease to the acquired immunodeficiency syndrome with a rising helper T-cell count and no development of opportunistic infections.
Report of a Case
A 51-year-old black male airplane mechanic with frequent and long-term expsoure to chemicals and solvents presented in 1988 with widespread erythema, exfoliation, and scaling plaques on the trunk. A serologie test for syphilis was positive at 1:32 and confirmed with a reactive fluorescent treponemal antibody-absorption test. Treatment for syphilis led to no improvement of the eruption but return of the VDRL to negative in 1 year. Serologie testing for HIV was positive. At the time of the diagnosis of HIV, his helper T-cell count was 0.50×109/L and the helper-to-suppressor ratio was 1:1. Over the next 4 years, his skin eruption became more
Berger TG, Kerschmann RL, Roth R, Schulze K, Zackheim HS. Sézary's Syndrome and Human Immunodeficiency Virus Infection. Arch Dermatol. 1995;131(6):739-741. doi:10.1001/archderm.1995.01690180119029