Human parvovirus B19 has been recognized as the causative agent of a number of cutaneous eruptions, including classic erythema infectiosum or fifth disease; some less well-defined, often purpuric, acute exanthematous eruptions; vasculitis; and the recently described petechial glove-and-sock syndrome.1,2 On the other hand, acute infection with parvovirus B19 may trigger a number of visceral manifestations. We report a new cutaneous manifestation of parvovirus B19 as a primary infection with a striking generalized livedo reticularis, occurring simultaneously with an impressive myasthenialike muscular weakness.
Report of a Case.
A 29-year-old woman was first referred to our institution in December 1993 for the evaluation of a recent, generalized livedo reticularis with fever and general alteration in her health. Her medical history was unremarkable, and she denied taking any medication. The disease began about 4 days before her admission to the hospital; it had an acute onset, consisting of a temperature as high as 40°C and chills, rapidly followed by generalized and increasing muscular weakness, and, eventually, by an extensive livedo reticularis. Initial examination revealed an acutely ill, febrile patient (temperature, 38°C) with myalgias and impressive
Dereure O, Montes B, Guilhou JJ. Acute Generalized Livedo Reticularis With Myasthenialike Syndrome Revealing Parvovirus B19 Primary Infection. Arch Dermatol. 1995;131(6):744-745. doi:10.1001/archderm.1995.01690180124033